McCaffrey is battling Achilles tendinitis that first cropped up in Week 17 last season. There was some hope he’d return for the season opener, but he missed that game before landing on the injured list where he’s been since Week 2 with no firm timetable for his return.

The San Francisco 49ers lost another running back on Thursday night, with fill-in starter Jordan Mason exiting Week 6's victory over the Seattle Seahawks with a shoulder injury. They'll have to make do,