Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The Arizona Cardinals suffered another blowout loss. On Sunday at State Farm Stadium, they gave up a 98-yard kickoff return to start the game and fell behind 14-0. Jacoby Brissett set an NFL record with 47 pass completions, but he threw two interceptions, and the 49ers dominated, cruising to a 41-22 victory.

The San Francisco 49ers face their division rivals, the Arizona Cardinals, at State Farm Stadium in Glendale, Arizona on Sunday, Nov. 16 at 1:05 p.m. PDT. 49ers as NFC's No. 1 seed? Don't laugh — the path is clear Contender or pretender: Could Bears ...

Both the 49ers and Panthers are coming off a win, but which team will make it two in a row?

The San Francisco 49ers will take on the Arizona Cardinals on Sunday afternoon at State Farm Stadium in a division matchup that could result in Kyle Shanahan's squad sweeping the season series against Jonathan Gannon's. On Saturday, San Francisco announced ...

Christian McCaffrey and the San Francisco 49ers (6-4) will visit Trey McBride and the Arizona Cardinals (3-6) on Sunday at 4:05 p.m. ET, in a matchup between a pair of the brightest stars in the NFL. The 49ers are compiling 356.2 yards per game on offense ...