The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, acting as a metabolic sensor that responds to changes in intracellular AMP/ATP ratios. When cellular ...

Metastatic cells are characterised as being highly invasive but weakly adhesive with rounded-amoeboid like features. These cells harbour high levels of cortical Myosin II activity and exert low ...

Discover how exercise reduces the risk of diseases by triggering a hormetic response in our cells and enhancing mitochondrial function. Learn how the Yan lab's research on AMPK could pave the way for ...

Calorie restriction (CR) is a dietary intervention that promotes various metabolic changes. CR-induced lithocholic acid (LCA) production has been associated with improved life expectancy and many ...

In a recent study published in the journal Science Advances, researchers tested whether low, clinically relevant doses of metformin lower blood glucose via inhibition of Ras-related protein 1 (Rap1) ...