Growth cones at the tips of nascent and regenerating axons direct axon elongation. Netrin-1, a secreted molecule that promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMP (cAMP) ...

cAMP is an evolutionary conserved, prototypic second messenger regulating numerous cellular functions. In mammals, cAMP is synthesized by one of 10 homologous adenylyl cyclases (ACs): nine ...

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme ...

We found a Japanese family with hyperthyroidism without autoantibody. DNA sequence analysis of TSHR was undertaken in this family. The functional consequences for the Gs-adenylyl cyclase and ...

Researchers have elucidated an important part of a signal pathway that transmits information through the cell membrane into the interior of a cell. This signal pathway is of great significance for all ...

My laboratory conducts molecular genetic and chemical genetic research using the fission yeast Schizosaccharomyces pombe. Initially, we studied how extracellular glucose triggers repression of ...

The probability of developing bipolar disorder in the course of an individual's life is around one percent. This means that it affects around 2.5 million people in Germany. The affective disorder is ...

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme ...