One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein’s activity can be modulated by binding an ...

Anapleurosis is the filling of the tricarboxylic acid cycle with four-carbon units. The common substrate for both anapleurosis and glucose phosphorylation in bacteria is the terminal glycolytic ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...

Yale scientists have taken a novel approach to unraveling the complex structure and regulation of enzymes: They Googled it. In a new study published online this week in the Proceedings of the National ...

Researchers at Yale say they used Google to help unravel the complex structure and regulation of enzymes. In a new study, “Eigenvector centrality for characterization of protein allosteric pathways,” ...

Scientists have, for the first time, observed one of the natural mechanisms underlying the regulation of the levels of growth inhibiting hormone in plants. This mechanism had been hitherto seen in ...

In a recent study posted to the bioRxiv* pre-print server, researchers investigated allosteric binders of angiotensin-converting enzyme 2 (ACE2) that significantly inhibit severe acute respiratory ...

Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases. Scientists have created a new ...

Many enzymes have their activities turned up or down by means of effectors—molecules that bind to enzymes and alter their shapes. At least one enzyme, however, responds to effectors by changing its ...