CCCTC-binding factor (CTCF) is an architectural protein that can mediate both interchromosomal and intrachromosomal interactions. The functional outcomes of these interactions depend on the nature of ...

The rapid scientific advancements that followed the mapping of the human genome have revealed just how staggeringly complex the world of genetics is. We now know that proteins are not just the ...

(Memphis, Tenn.—January 25, 2023) CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children’s Research Hospital used a ...

CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation ...

Mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed to cancer, new research demonstrates. CTCF is a very well-studied DNA binding protein that exerts ...

In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor ...

Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...

Please note - this trial is no longer recruiting patients. We hope to add results when they are available. This study is looking at proteins called CTCF and BORIS in blood and samples of tissue ...

Scientists used the auxin-inducible degron 2 system on CTCF, bringing the novel approach to bear on a fundamental protein. CTCF is a critical protein known to play various roles in key biological ...