Molecular glues are revolutionizing cancer therapy by targeting undruggable proteins for degradation, enhancing precision ...

When blood cancer in children progresses particularly aggressively, it is often due to a genetic defect: a gene fusion, such ...

The publication reports the highly selective, DCAF16 E3 enabled degradation of BRD9 in vivo using Amphista’s proprietary, next generation Targeted Glue™ medicinal chemistry technology Amphista’s ...

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability. Researchers from the Bhogaraju Group at ...

Ethylene influences plant growth, development, and stress responses via crosstalk with other phytohormones; however, the underlying molecular mechanisms are still unclear. Here, we describe a ...

Journal of Experimental Botany, Vol. 62, No. 2 (2011), pp. 775-785 (11 pages) Ubiquitination plays important roles in plant growth and development. Whereas ubiquitin-dependent protein degradation and ...

Outrun Therapeutics has launched with $10 million in seed financing. The company spun out of Satpal Virdee’s lab at the University of Dundee and is focused on stabilizing proteins, or keeping ...

If I weren’t a chemist, I’d be: A sustainability scientist. “Both drug discovery and sustainability have the goal of making sure more people can live long, healthy lives.” If I were an element, I’d be ...