In vertebrates, unfertilized eggs are arrested at metaphase of meiosis II by Emi2, a direct inhibitor of the APC/C ubiquitin ligase. Two different ubiquitin-conjugating enzymes, UbcH10 and Ube2S, work ...
In a mammalian oocyte, completion of meiosis is suspended until fertilization by a sperm and the cell cycle is arrested by a biochemical activity called cytostatic factor (CSF). Emi2 is one of the ...
When producing our germ cells—egg and sperm—a special feature is required in the cell division process: Since male and female germ cells fuse during fertilization, the chromosome set of our genetic ...
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