We have previously demonstrated an apparent decrease in renal tubular secretion and an increase in plasma half-life for furosemide (F) in VLBW infants. To pharmacokinetically characterize ...

Furosemide 10mg/mL, 40mg/5mL. Furosemide inhibits primarily the absorption of sodium and chloride in the proximal and distal tubules, and in the loop of Henle.

However, sodium excretion falls to very low levels during the remaining 18 hours of the day because the volume depletion from the furosemide leads to activation of sodium-retaining mechanisms ...