Signal peptide-CUB-EGF domain-containing proteins constitute a family of multifunctional glycoproteins that play pivotal roles in both developmental processes and a range of diseases. Their highly ...

Pediatric Precision Medicine at the National Cancer Center Japan: Prospective Genomic Study of Pediatric Patients with Cancer as Part of the TOP-GEAR Project HER2 status was evaluated using ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

Organoids have rapidly become revolutionary tools in biomedical research, transforming approaches to drug discovery and disease modeling. These three-dimensional cell culture models have the ...

To update ASCO–College of American Pathologists (CAP) recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer. The Panel is aware that a new generation of antibody ...

Stem cells are a class of multipotential cells that can self-replicate, self-renew, and differentiate into multiple cell lines. Stem cells provide a more realistic method of identifying and confirming ...

To understand how cells behave, researchers also need to understand the molecules that make them work. "If someone wants to know how the kidney functions, they have to know what's going on inside the ...

Transplanting a human protein, known for promoting growth, into crops may engender larger, heavier and more bountiful plants. jxfzsy/Getty Images Every year, 9 million people in the world succumb to ...

The full set of proteins expressed in the human body, commonly called the proteome, is central to understanding how health is maintained and how disease arises. Researchers rely on detailed maps ...

Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein ...

Despite vaccines and treatments, SARS-CoV-2—the virus that causes COVID-19—continues to pose a global health threat, driven by new variants and its ability to hijack human cells in ways that still ...