Integrins are heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix and engage bidirectional signalling across the plasma membrane. Activation is controlled by ...
Concept figure summarizing the proposed regulatory axis connecting extracellular matrix mechanics to integrin signaling and receptor trafficking in joint cells. In a new review, researchers from ...
Integrin αIIbβ3 is the principal adhesion receptor on platelets and serves as a fulcrum for bidirectional signal transduction that underpins haemostasis and thrombosis. In resting platelets, αIIbβ3 ...
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