Jonathan Silverberg, MD, PhD, MPH, associate professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences, discusses ...

Positron emission tomography (PET) and estrogen receptor (ER) ligand in patients with invasive breast cancer. Germline single nucleotide polymorphisms (SNPs) in XRCC3, XRCC1, and XPD, and survival ...

SAN DIEGO — Researchers found JAK-STAT mutations in a predominance of a cohort of adults with fusion-free hypereosinophilia with features suggesting myeloid neoplasms, according to data presented at ...

Acute myeloid leukemia (AML) is a deadly hematologic malignancy with poor prognosis, particularly in the elderly. Even among individuals with favorable-risk disease, approximately half will relapse ...

Dr. Norbert Perrimon and colleagues at Harvard Medical School (Boston, MA) have used a genome-wide RNAi screen in cultured Drosophila cells to identify novel regulators of the JAK/STAT signaling ...

The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway was discovered 20 years ago as a mediator of cytokine signaling. Since this time, more than 2,500 articles have ...

Research led by a University of Maryland team has identified the first inter-species signaling pathway between an arthropod parasite and host, where molecules in the blood of a host animal triggers ...

TYK2 is a key component of the JAK-STAT signalling pathway and is involved in the pathology of inflammatory diseases.

JAK3 inhibitors have become a buzzword in pharmaceuticals, with significant implications for treating various diseases, including autoimmune disorders and cancers. JAK (Janus Kinase) inhibitors, ...