The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system 1, 2 and has been ...

To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. HepG2 cells ...

New research indicates that drugs that target a cell growth pathway known as the JAK-STAT pathway are likely to be effective against certain chronic leukemias. Researchers recently discovered that a ...

Ischemic stroke is a major cause of death and disability, caused by a sudden loss of oxygen supply to the brain due to blocked blood vessels. Recanalization treatments such as intravenous thrombolysis ...

Jonathan Silverberg, MD, PhD, MPH, associate professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences, discusses ...

Cosmetic outcome after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: An objective assessment of patients from a randomized controlled trial. Effect of adjuvant ...

Positron emission tomography (PET) and estrogen receptor (ER) ligand in patients with invasive breast cancer. Germline single nucleotide polymorphisms (SNPs) in XRCC3, XRCC1, and XPD, and survival ...

What a difference an amino acid makes. Five years ago, researchers noticed that many patients with rare blood cancers called myeloproliferative neoplasms, or MPNs, had a phenylalanine in place of a ...

John Mascarenhas, MD: So JAK inhibitors are a class of agents. They’re oral agents. There are probably at least a dozen that have been in clinical development. And what they do is potently inhibit a ...

Myeloproliferative neoplasms (MPNs) represent a cluster of conditions characterized by the excessive production of blood cells within the bone marrow. Among MPN patients, abnormal quantities of red ...

Scientists at Children’s Hospital of Philadelphia (CHOP) say they have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway ...