A discovery from Australian researchers could lead to better treatment for children with neuroblastoma, a cancer that ...

New research has identified a drug combination that can bypass the cellular defences of neuroblastoma that lead to relapse.

Scientists have discovered a drug combo that may bypass tumor defenses, offering new hope for children with high-risk ...

According to Australia’s Garvan Institute of Medical Research, the drug combination can bypass the cellular defences these ...

The cancer occurs commonly in children, and is deadly in nine out of 10 cases when children relapse.

Discovered in the 1990s, the JNK protein, or, to give it its full name, c-Jun NH 2-terminal kinase, was found to be the protein kinase responsible for the phosphorylation of c-Jun at Ser-63 and Ser-73 ...

The glutamate-induced excitotoxicity pathway has been reported in several neurodegenerative diseases. Molecules that inhibit the release of glutamate or cause the overactivation of glutamate receptors ...

Morphologic and genomic characterization of circulating tumor cells in patients with metastatic colorectal cancer treated with combinational treatment of andecaliximab, bevacizumab and chemotherapy.

The TNF–JNK pathway is a highly conserved signaling pathway that regulates a wide spectrum of biological processes including cell death and migration. To further delineate this pathway, we carried out ...

Sirtuin 3 (Sirt3)-modified mitochondrial fission participates in the progression of several types of cancers. However, its role in tongue cancer requires investigation. The aim of our study is to ...

A study led by Garvan researchers has uncovered why some breast cancers become resistant to treatment, potentially opening the door to more effective therapies for patients. Published today in the ...