Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.

The hero at the heart of “Novocaine” can't feel pain. The new film in theaters Friday stars Jack Quaid as Nate, an ordinary guy whose disability becomes his saving grace when attempting to save a hostage from violent criminals.