Obesity prevalence continues to increase at an alarming rate, but current therapies are limited by side effects and modest efficacy. Now, writing in Cell Metabolism, Ozcan and colleagues show that ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

Researchers have uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity: leptin resistance. They found that mice fed a high-fat diet ...

Baltimore, MD - The natural hormone leptin or a component of its signaling pathway can reverse obesity-associated left ventricular hypertrophy (LVH) independent of body weight, a study in mice at ...

Please provide your email address to receive an email when new articles are posted on . Leptin adjusted fat mass is greater among women who eat more ultraprocessed ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in ...

A paper published in the May issue of Diabetes implicates triglycerides in the mechanism of leptin resistance. These fats, elevated in obesity, are what disrupt the transport of the hormone across the ...

A new study has discovered a previously unidentified mechanism explaining how obesity and high-fat diets can disrupt the appetite-suppressing signals from the brain and lead to overeating. The ...

Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...