If you had to swallow a pouch of toxins, you’d like to be certain the pouch was indestructible. Similarly, every eukaryotic cell seeks to ensure that the membranes of its many miniscule sacs called ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell ...

The Lysosomal Metabolomics and pH Core’s overarching goal is to understand the mechanistic link between lysosomal activity and aging in Alzheimer’s Disease. To accomplish this, the core will support ...

The osteoclast is a polarized cell which secretes large amounts of newly synthesized lysosomal enzymes into an apical extracellular lacuna where bone resorption takes place. Using immunocytochemical ...

Macrophages are the specialized phagocytic cells that respond to toxic particle depositions to exert inflammatory and clearance responses. These long-lived immune cells engulf foreign substances like ...

Mannose 6-phosphate (Man-6-P)-dependent trafficking is vital for normal development. The biogenesis of lysosomes, a major cellular site of protein, carbohydrate, and lipid catabolism, depends on the ...

Dealing with trash poses a constant challenge not only for municipalities but also for neurons, where specialized organelles called lysosomes take on the task. A Science paper published online 25 June ...

Lysosomal acid lipase deficiency is a rare genetic condition that causes fat to build up in your body’s cells, especially in your liver and spleen. Lysosomal acid lipase deficiency (LALD) is a rare ...

Efforts to take down the activity of glycogen synthase kinase 3 (GSK3)—a pivotal kinase that promotes pathology in Alzheimer’s disease—have come up short. Now, a new class of inhibitor may provide a ...

The MarketWatch News Department was not involved in the creation of this content. PARMA, Italy, Nov. 12, 2025 (GLOBE NEWSWIRE) -- Chiesi Group today announced it has entered into an exclusive license ...