Diabetes affects millions worldwide, often triggering complications such as insulin resistance and fatty liver disease. To ...

The increasing popularity of weight loss drugs like Wegovy, Ozempic, Mounjaro and metformin may have you wondering how all these options stack up.

Certain medications and toxins can also lead to type B lactic acidosis. A prime example is a diabetes drug called metformin. Metformin works in the liver and gut to lower blood sugar levels ...

Indeed, phenformin, an antidiabetic drug that belongs to the same class as metformin, was withdrawn from the market in 1977 because of the high incidence of lactic acidosis associated with its use.

Lactic acidosis (a buildup of lactic acid in your blood) is a potential serious side effect of metformin. Signs of this condition include feeling dizzy, having unusual muscle pain or a slow or ...

hypoglycemia and vitamin B12 deficiency (with long-term metformin use). A rare but serious side effect is lactic acidosis, with risk factors being older age, having a history of alcoholism and ...

In severe cases, metformin may cause lactic acidosis. Lactic acidosis is a dangerous complication that causes a buildup of lactic acid in the body. This can lead to diabetic coma and might even be ...

Objective Many societies recommend using estimated glomerular filtration rate (eGFR) rather than serum creatinine (sCr) to determine metformin eligibility. We examined the potential impact of ...

Metformin-associated lactic acidosis was associated with elevated blood lactate levels (>5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ...

In 1996, the Food and Drug Administration approved the labeling for metformin (dimethylbiguanide ... in 1977 because of an association with lactic acidosis. Buformin, another biguanide, is ...

Glyburide, metformin HCl; 2.5mg/500mg ... See Contraindications. Increased risk of lactic acidosis with topiramate, other carbonic anhydrase inhibitors (eg, zonisamide, acetazolamide ...