The Hidetoshi Sakurai Laboratory at CiRA has successfully reproduced the pathology of Myotonic Dystrophy type 1 (DM1) using skeletal muscle cells generated from patient-derived iPS cells and ...

These results suggest that miR-1 and miR-206 are potent targets for rescuing the skeletal muscle pathology in SMA. This study has identified one of the pathogenic mechanisms of skeletal muscle lesions ...

QMUS may serve as a reliable, non-invasive biomarker for monitoring DMD progression and functional status, addressing limitations of traditional assessments. Strong correlations were found between ...

Human movement is reciprocal in nature: Opposing muscle groups must coordinate for proper movement. Muscle length and strength between opposing muscle groups need to be in balance for normal movement ...