Hemodynamic forces and Notch signaling are both known as key regulators of arterial remodeling and homeostasis. However, how these two factors integrate in vascular morphogenesis and homeostasis is ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Delta-like ligand-3 (DLL3) is a single-pass, type I transmembrane protein that inhibits the Notch signaling pathway. A highly conserved intercellular signaling pathway, the Notch signaling pathway ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Researchers have made a surprising discovery linking Delta/Notch signaling in subperineurial glia (SPG) to the regulation of nerve ensheathment and neurotransmitter release at the Drosophila ...

Oxidative modification of proteins of blood plasma in the development of ovarian cancer relapse. This is an ASCO Meeting Abstract from the 2013 ASCO Annual Meeting I. This abstract does not include a ...

A new study led by researchers at Hospital for Special Surgery identifies the mechanism by which a cell signaling pathway contributes to the development of rheumatoid arthritis (RA). In addition, the ...

(A) The mRNA expression levels of Hey1 and Hes1 in each treatment group were measured by quantitative real-time PCR. (B) Western blot analysis of NICD expression in the cytoplasm and nucleus in each ...

Prism Biolab Co. Ltd. has identified new 7-membered ring-fused compounds acting as Notch signaling inhibitors and reported to be potentially useful for the treatment of neuronal injury and ...