Domain structure of the unrearranged PML protein and P/R fusion proteins. Note the same RBCC domain (e.g., RING finger, B-box, and coiled-coil) in the N-terminus but different in the C-terminus.
Most proteins in cells are composed of multiple folding units (or domains) to perform complex functions in a cooperative manner. Relative to the rapid progress in single-domain structure prediction, ...
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