Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer The PI3K/Akt/mTOR pathway is activated in the majority of pancreatic cancers, and inhibition of ...
The rationale for combination therapy with an AKT inhibitor and abiraterone is based on observations that aberrant activation of both the PI3K–AKT–mTOR pathway and androgen receptor (AR) signaling are ...
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Early Promise for PI3K Inhibitor in Brain Metastases
HOUSTON -- Two-thirds of patients with PI3K-mutant brain metastases responded to the maximum tolerated dose (MTD) of the small-molecule inhibitor paxalisib plus radiation therapy (RT), a small phase I ...
Variational AI’s Enki™ generative AI platform designed novel ATR/mTOR dual inhibitors with brain penetrance and activity in ...
Celcuity Inc. (Nasdaq: CELC), a clinical-stage biotechnology company pursuing development of targeted therapies for oncology, today announced the completion ...
Rakovina Therapeutics Inc., a biopharmaceutical company advancing cancer therapies through AI-enabled drug discovery, has announced impressive results from its AI-enabled ATR program at the recent ...
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