An aggressive breast cancer lacking common drug targets, triple-negative breast cancer may be countered by oridonin, a ...

The phosphatidylinositol 3-kinase (PI3K) signaling axis impacts on cancer cell growth, survival, motility, and metabolism. This pathway is activated by several different mechanisms in cancers, ...

Experts in cell signaling at the Babraham Institute have identified how prostate cancer cells achieve cell growth free from the usual growth cues and regulators. This discovery has implications for ...

Low-dose aspirin reduced colorectal cancer (CRC) recurrence rates by more than half in patients with tumors harboring mutations in the PI3K signaling pathway, according to findings from the phase 3 ...

In the age of precision medicine, targeted drugs are transforming cancer treatment. But cancer cells persist in many patients, even in breast cancer, where much-lauded hormone therapies and targeted ...

Scientists have flipped the script on a common cancer target in an effort to regenerate nerves and protect cardiac tissue from damage. “There are currently no approved medicines to regenerate nerves [ ...

An international research team has identified a previously unknown mechanism by which the breast cancer drug tamoxifen can increase the risk of secondary tumors in the uterus. The study shows that ...

The researchers found that after 3 years of follow-up, time to recurrence was lower for participants assigned to aspirin versus placebo. A similar trend was seen for disease-free survival hazard ...