Perhaps no topic is hotter in Alzheimer disease molecular research today than the synaptic effects of amyloid-β (Aβ) oligomers. These toxic assemblies disrupt synaptic function, and are leading ...

Cells have certain proteins that help them adhere to each other while covering body surfaces and organs. Loss of these identifying proteins could result in cellular progression towards cancer and, ...

The regeneration of a signaling molecule, phosphatidylinositol 4,5 bisphosphate (PIP2), is not as simple as it was thought to be. Experimental work and mathematical modelling show that the decades-old ...

Researchers have captured the first cryo-electron microscopy snapshots of the cold-sensing ion channel TRPM8 in its open state at low temperature, identifying the membrane lipid PIP2 as the molecular ...

A recent study brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2. A recent study in the Journal ...