Identification of the mechanisms of innate immune sensors is fundamental to the understanding of health and disease. The pattern recognition receptor (PRR) subfamily of nucleotide-binding ...
Figure 1: PAMP-PRR interaction in the innate immune response to HIV-1 infection. Remarkably, when monocyte-derived dendritic cells from HIV-1–infected people were exposed to capsid-mutant HIV-1 ...
The innate immune system can detect bacteria by sensing their cell-wall-associated molecules, including lipopolysaccharide, lipoproteins, peptidoglycan and flagellin. Each of these types of molecules ...
BOSTON -- Inflammation is at the root of most serious complications occurring after both infection and injury. But while the molecular course of events that leads from microbial infections to the ...
Researchers present comprehensive evidence that supports a novel trigger for a cell-mediated response and propose a mechanism for its action. Viruses and other disease-causing microbes influence the ...
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