PISARRO: A EUTROC phase Ib study of APR-246 in combination with carboplatin (C) and pegylated liposomal doxorubicin (PLD) in platinum sensitive relapsed high grade serous ovarian cancer (HGSOC). This ...
Criteria defining the duration of chemoreduction with focal treatment in retinoblastoma: A retrospective analysis. Background: Caffeine is a radio- and chemo-sensitizing agent acting by inhibiting ATM ...
Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of immature B cells remains ...
The molecular evolution of placental protein NRK and its function in regulating placental growth has finally been clarified. They elucidated that eutherian NRK regulates placental development by a ...
Circadian rhythms are endogenous oscillations widely present in living organisms, typically following approximately 24-hour ...
Chronic myeloid leukemia (CML) is a hematological tumor marked by the bcr-abl fusion gene formed by t (9;22) (q34;q11), which translated into the BCR-ABL protein. Tyrosine kinase inhibitors (TKIs) ...
Variational AI’s Enki™ generative AI platform designed novel ATR/mTOR dual inhibitors with brain penetrance and activity in ...
A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research ...
Cancer develops when cells known as cancer stem cells begin to divide in an uncontrolled manner. Researchers from the University of Michigan Comprehensive Cancer Center have identified roles for the ...
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