Leucine-rich repeat-containing 8A (LRRC8A) is a ubiquitously expressed transmembrane protein that functions as the essential component of volume-regulated anion channels (VRACs). These channels are ...

(A) Multiple environmental and genetic factors have been associated with MASLD. Most significant ones are highlighted here. (B) Several strong genetic risk factors for MASLD are highlighted here. ALT, ...

Colon, lung, and liver cancers are among the most prevalent and lethal cancers globally. Despite advancements in treatment, these cancers continue to pose significant challenges due to high mortality ...

While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC remain unclear. This insightful review, published in Hepatology, ...

Analysis of Alzheimer’s brains revealed age-related accumulation of cancer driver mutations, particularly in microglia. These ...

Multi-omics describes the integration of multiple high-throughput screening technologies based on genomics, proteomics, transcriptomics, single-cell transcriptomics, metabolomics, and more, which all ...

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma-cell disorder present in approximately 5% of the general population over the age of 50 years. MGUS is characterized ...

A research team at the University of Cologne's Center for Molecular Medicine Cologne (CMMC) has discovered that the protein ...

Although autoantibody profiling has enhanced risk stratification and informed cancer screening strategies in DM, substantial therapeutic challenges remain.