Purpose. A pooled analysis of six clinical studies was conducted to describe the pharmacokinetics of extended-release epidural morphine sulfate. Methods. Data from six clinical studies evaluating ...

Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...

Julie Blendy, professor of pharmacology at University of Pennsylvania’s Perelman School of Medicine, presented her research on the molecular and genetic mechanisms behind opioid use disorders in the ...

A little-known morphine-like drug is potentially more potent, longer lasting and less likely to cause constipation than standard morphine, a study has found. The drug also is less likely to cause ...

Opioids are naturally occurring substances that have several effects on the central nervous system that are mainly mediated by opioid receptors. There are three subtypes of this receptor (μ1, μ2 and ...

Morphine is the most abundant analgesic opiate found in opium and is a potent pain reliever. The drug is used in clinical pain relief but is also used illicitly for recreational purposes among drug ...

A painkiller has been developed that is as strong as morphine but isn't likely to be addictive and with fewer side effects, according to a new study. Opium-based drugs are the leading treatments for ...

Am J Health Syst Pharm. 2009;66(11):1020-1030. Certain populations had slight variations in several pharmacokinetic parameters. Body weight differences between men and women most likely caused the 25% ...