Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

San Francisco, Dec. 4, 2000 -- Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM) today announced the presentation of preclinical and clinical study results demonstrating that an investigational ...

A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

During cell division, adherent animal cells round up to create the precise spatial geometry required for accurate chromosome segregation, a process that depends on the coordinated remodeling of the ...

Edited By: Karen Young Kreeger C.L. Ward, S. Omura, R.R. Kopito, "Degradation of CFTR by the ubiquitin-proteasome pathway," Cell, 83:121-7, 1995. (Cited in nearly 50 publications as of March 1997) ...

While traditional induction therapy for newly diagnosed stage 2 myeloma often focuses on combinations of proteasome inhibitors, immunomodulatory drugs, and steroids, these newer immunotherapy classes ...

Stage 1 multiple myeloma features low beta-2 microglobulin, high albumin, and no organ damage, often detected incidentally. Diagnosis involves blood, urine, imaging tests, and bone marrow biopsy to ...