Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome ...

A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate ...

The proteasome is a barrel-shaped protease that conceals its active sites within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in some cases, ...

As we get older, our brains start to change in ways that make them increasingly vulnerable to disease – and a detailed new ...

Proteasome helps in maintaining appropriate levels of proteins within cells. It degrades unneeded or defective proteins to recycle the components for the eventual assembly of new proteins. Deficient ...

There is an urgent need for new antimalarial drugs because the malaria parasite has developed resistance to the most widely used therapies—combinations of artemisinin and other drugs—and most ...

Booster Therapeutics is developing a novel therapeutic approach that aims to combat the accumulation of deviant proteins in cells, which are a major driver of Parkinson's and other complex diseases ...

Related to many severe neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and certain types of cancer is the dysfunction of the ubiquitin-proteasome system. Such dysfunction is ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Oral weekly MLN9708, an investigational proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients (pts) with previously untreated multiple myeloma (MM): A phase I/II study.

Data Bridge Market Research has added a new report titled Global Proteasome Inhibitors Market Size, Share, Growth, Industry Trends and Forecast to 2028 in its database, which describes a systematic ...