RESEARCHERS AND COMPANIES frequently turn to Escherichia coli to provide an ample supply of proteins for experimental or therapeutic use. But proteins overexpressed in bacteria are frequently unusable ...

Scientists routinely express heterologous proteins in Escherichia coli. However, these proteins may not fold properly in the bacteria, causing them to aggregate and form insoluble inclusion bodies.

Precision medicine is becoming increasingly important, achieving to create more efficient personalised therapies for each patient and innovative pharmacological developments. In the oncology field, ...

Transactive response DNA/RNA-binding protein 43-kDa (TDP-43) C-terminal fragments, such as a 25-kDa fragment (TDP-25), have been identified as a ubiquitinated and phosphorylated components of ...

Precision medicine is becoming increasingly important, achieving to create more efficient personalized therapies for each patient and innovative pharmacological developments. In the oncology field, ...

Microbial systems offer distinct advantages in protein expression, saving costs and time, and offering well-characterized host genetics and ease of scale-up. 2 However, challenges remain in process ...

Inclusion bodies play a protective, not pathogenic, role in Huntington disease, according to a recent study by Steven Finkbeiner of the Gladstone Institute of Neurological Disease at the University of ...

Huntington's disease is a progressively debilitating brain disease that causes uncontrolled movements, psychological problems, and loss of cognition. Huntington's is caused by a mutation in the gene ...

The storage reserves of seeds of a wide taxonomic range of Proteaceae were examined by chemical analyses for macronutrients, protein and non-protein-N composition, by light microscopy of cotyledonary ...

Pichia pastoris is emerging as a versatile, efficient alternative for protein production, bridging microbial and mammalian expression systems.