Ubiquitin-positive protein inclusions are a hallmark of frontotemporal dementias and other neurodegenerative diseases. In some cases, the aggregating proteins are known, such as the tau protein in ...

RESEARCHERS AND COMPANIES frequently turn to Escherichia coli to provide an ample supply of proteins for experimental or therapeutic use. But proteins overexpressed in bacteria are frequently unusable ...

Inclusion bodies, once considered a hindrance in recombinant protein production, are now recognised for their potential as reservoirs of bioactive proteins and functional biomaterials. In bacterial ...

When it comes to cleaning house, neurons are no slouches. Considering the number of neurodegenerative diseases that are triggered by the accumulation of protein garbage, it is clear that these cells ...

Precision medicine is becoming increasingly important, achieving to create more efficient personalized therapies for each patient and innovative pharmacological developments. In the oncology field, ...

Scientists routinely express heterologous proteins in Escherichia coli. However, these proteins may not fold properly in the bacteria, causing them to aggregate and form insoluble inclusion bodies.

The storage reserves of seeds of a wide taxonomic range of Proteaceae were examined by chemical analyses for macronutrients, protein and non-protein-N composition, by light microscopy of cotyledonary ...

Inclusion bodies play a protective, not pathogenic, role in Huntington disease, according to a recent study by Steven Finkbeiner of the Gladstone Institute of Neurological Disease at the University of ...

Huntington's disease is a progressively debilitating brain disease that causes uncontrolled movements, psychological problems, and loss of cognition. Huntington's is caused by a mutation in the gene ...