Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

When Krebs proposed the TCA cycle in 1937, he thought that citrate was synthesized from oxaloacetate and pyruvate (or a derivative of it). Only after Lipmann's discovery of coenzyme A in 1945 and ...

allowing pyruvate to enter the TCA cycle. In the absence of MCT1 in skeletal muscle, both lactate uptake by oxidative muscle ...

Specifically, the scientists found that pyrimidines maintain the activity of an enzyme called pyruvate dehydrogenase, which ...

PDHX acetylation promotes tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression.