Glycolysis, Pyruvate Oxidation and the Krebs Cycle Glycolysis, the process of splitting a six-carbon glucose molecule into two three-carbon pyruvate molecules, is linked to the Krebs cycle.

Last year, Joseph Moran of the University of Strasbourg and coworkers reported that they could recapitulate the Krebs cycle by mixing pyruvate and glyoxylate in the presence of ferrous ion (Nature ...

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

The research reveals significant reduction in the citric acid cycle intermediates and key enzyme gene expressions by 6-PPDQ ... Acetyl CoA generated from pyruvate is a key substrate for the cycle.

A central pillar of all cellular metabolism — and the bane of generations of high school biology students who had to memorize it — is a complex 10-step chemical process variously known as the ...

Calcium ions regulate the citric acid cycle by activating pyruvate dehydrogenase, the first component of the pyruvate dehydrogenase complex reaction that forms acetyl-CoA.

Also known as the citric acid cycle, ... Last year, the group demonstrated how pyruvate could form without enzymes through a reaction involving CO 2, iron, cobalt, and nickel.

US-based researchers found that mixing glyoxylate and pyruvate together in warm water produced myriad chemicals, including those similar to what are seen in the Krebs cycle.

Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...