Figure 3: Various scaffolds utilized to engineer binders to Ras and their binding epitopes. Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras genes are associated ...
At AACR 2022 (8th–13th April) in New Orleans (LA, USA), we caught up with Kevan Shokat, Professor at the University of California, San Francisco (UCSF; CA, USA), and Investigator at Howard Hughes ...
The first therapeutic monoclonal antibody (MAb) that selectively targets activated intracellular cytosolic Ras mutant proteins, which are inaccessible to current antibodies, has been developed and ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 11 (March 16, 2021), pp. 1-6 (6 pages) The prevalent view on whether Ras is druggable has gradually ...
The molecular basis of host-cell permissiveness to herpes simplex viruses (HSV) is under intense investigation because of HSV prevalence in human disease and its potential use as an anti-cancer ...
This year's Sjöberg Prize in cancer research of one million dollars is awarded to professor Kevan Shokat, University of California, USA. Ten years ago, he became the first person to succeed in ...
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