RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from the Institute of Science, Tokyo, Japan. Using ...
Computer-Aided Aptamer Modeling and Optimization (CAAMO) enables structure-guided RNA aptamer affinity maturation, producing a SARS-CoV-2 RBD (receptor binding domain) binder that rivals neutralizing ...
A research team at Florida State University's Institute of Molecular Biophysics and Department of Chemistry and Biochemistry has discovered how a protein found in the human body interacts with RNA in ...
Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...
In 2021, research led by Ryan Flynn, MD, Ph.D., and his mentor, Nobel laureate Carolyn Bertozzi, Ph.D., opened a new chapter in biology, characterizing a new kind of player on the cell surface: ...
In 2021, the lab of chemical biologist and Nobel Laureate Carolyn Bertozzi, PhD, professor at Stanford University, characterized a new type of cell-surface protein, termed glycoRNAs, that form highly ...
A Purdue University team has discovered a new therapeutic target for triple-negative breast cancer. The research, led by Kyle Cottrell, an assistant professor of biochemistry, spotlights ...
Low-complexity domains in proteins are composed of a small subset of the full complement of amino acids, and in these domains, the amino acid sequences are often repetitive. Their relevance to health ...
Cancer cells are metabolic opportunists, bending every pathway to fuel unchecked growth. Now UCLA scientists show that a single protein—Insulin-like Growth Factor 2 mRNA-Binding Protein 3 ...
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