Actin, spectrin, and related molecules form a membrane-associated periodic skeleton (MPS) in neurons. The function of the MPS, however, remains poorly understood. Using super-resolution imaging, we ...

In a recent study published in the journal EMBO Reports, researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases (RTKs), ...

Immuno-positron emission tomography (PET) imaging can provide early insight into a tumor's response to targeted therapy, allowing physicians to select the most effective treatment for patients who ...

Here, we report robust response to RTK inhibition of a patient with NB harboring a rare germline variant in the ALKAL2 gene with a chromosomal 2p gain and ALK and TRK activity. On the basis of this ...

Receptor Tyrosine Kinases select RTKs) regulate many critical processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. Dysregulated ...

Targeted anti-cancer therapies dramatically improve patient outcomes in EGFR-mutant lung adenocarcinomas, 1 but many tumors acquire resistance to these drugs over time. Because there are numerous ways ...