The solar system’s neglected stepchild until recently, the planet has now been scrutinized twice at close range by the MESSENGER spacecraft. The craft’s most recent flyby, on October 6, 2008, has ...

A new study describes the development of a cAMP analogue that specifically activates only Epac2, one of several cAMP-responsive proteins. Furthermore, the analogue activates Epac2 more potently than ...

Advanced Tools to Investigate All Compound Classes of GPCR Activation Among targets of interest for the pharmaceutical industry, GPCRs account for more than 30% of all drug screenings. The complexity ...

When Mariner 10 flew past Mercury three times in 1974 and 1975, the probe imaged less than half the planet. In January, during MESSENGER’s first flyby, its cameras returned images of about 20 percent ...

Scientist have created photosensitive mimics of a class of signaling molecules, thus enabling their actions to be regulated by light, and affording new insights into the communications networks that ...

NASA’s MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) spacecraft swung by Venus for the second time early this evening for a gravity assist that shrank the radius of its ...

NASA’s MESSENGER spacecraft will make its second flyby of the mysterious, rocky planet October 6. During the flyby, a detector from the University of Colorado at Boulder will measure Mercury’s wispy ...

The bacterial second messenger cyclic diguanylate (c-di-GMP) regulates a wide range of cellular functions from biofilm formation to growth and survival. Targeting a second-messenger network is ...