Even though the Shh pathway is mainly quiescent in adults, the safety of Shh-targeting with therapeutic antibodies was questioned initially because not only does the N-terminus of the Shh protein play ...
Scientists have identified a novel target for a type of pediatric brain tumor. Investigators at St. Jude Children's Research Hospital have found that the ABCC4 transporter is critical to the SHH ...
A randomized, open-label, phase III trial of NOV-002 in combination with paclitaxel (P) and carboplatin (C) versus paclitaxel and carboplatin alone for the treatment of advanced non-small cell lung ...
The clinical response to TKIs for patients with NSCLC is limited by primary and secondary resistance to the therapy and classic biomarkers cannot be used to predict which patients may develop such ...
To see if this affects the SHH pathway, they introduced the genes into cells lacking LRP2 function. "We were able to see that they significantly boost the Sonic Hedgehog signaling pathway," says ...
A research led by Hong Kong University of Science and Technology (HKUST) has revealed a novel mechanism that regulates secretion of sonic hedgehog (Shh), a key signaling molecular that plays an ...
Spurred on by these reports, Mohan and colleagues studied the incidence of subsequent non-BCC malignancies in a cohort of 180 patients (68.9% male) with high-risk BCCs (mean age at time of diagnosis, ...
Targeting the Insulin-Like Growth Factor (IGF) System Is Not as Simple as Just Targeting the Type 1 IGF Receptor Hedgehog (HH) signaling has been investigated for its role in tumorigenesis because of ...
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