Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Findings underpin the scientific rationale for Anavex’s targeted autophagy approach with orally administered blarcamesineConvergence of impaired ...

How do we learn something new? How do tasks at a new job, lyrics to the latest hit song or directions to a friend's house become encoded in our brains? The broad answer is that our brains undergo ...

New research on the hippocampus, a brain area essential for memory, suggests that new rules of synaptic plasticity best explain how brain activity continually reshapes the way memories are recorded in ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

There's a lot to love about coffee. From its delicious taste to its utterly intoxicating aroma, and the social ritual of ...

By adding, removing, strengthening, or weakening synaptic contacts, our brain encodes new events or forgets previous ones. In AD, synaptic plasticity, the brain's ability to regulate the strength of ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...

For decades, the scientific theory of depression focused on chemicals — serotonin, norepinephrine and dopamine. Nearly every ...

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...