Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is ...

Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and ...

T cell antigen receptor (TCR) signaling is essential for the differentiation and maintenance of effector regulatory T (Treg) cells. However, the contribution of individual TCR-dependent genes in Treg ...

CD3 (including its subunits CD3ε, CD3δ, CD3γ, and CD3ζ) is the central component of the TCR-CD3 complex and is crucial for recognizing T cells and responding to antigens. Every subunit of CD3 has ...

CYAD-01, one of Celyad's lead candidates, is an autologous NKG2D-based chimeric antigen receptor T-cell (CAR-T) therapy construct, consisting of a full-length native human NKG2D gene fused with the ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

Please provide your email address to receive an email when new articles are posted on . The world of cancer cell therapy continues to evolve, and the next breakthrough may include T cells genetically ...

Cartoon describing the synthesis process of the Nanogel (backpack). This material relates to a paper that appeared in the Nov. 11, 2020, issue of Science Translational Medicine, published by AAAS. The ...

In atopic dermatitis, psoriasis and other dermatologic diseases, T cells lose tolerance to self-antigens, triggering the autoimmune response that leads to abnormal skin cell proliferation and ...