Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is ...

Different subsets of γδ T cells display differential expression of immune checkpoint receptors (ICRs) and have distinct ...

Signaling via the T cell receptor (TCR) is critical during the development, maintenance, and activation of T cells. Quantitative aspects of TCR signaling have an important role during positive and ...

T cell antigen receptor (TCR) signaling is essential for the differentiation and maintenance of effector regulatory T (Treg) cells. However, the contribution of individual TCR-dependent genes in Treg ...

CD3 (including its subunits CD3ε, CD3δ, CD3γ, and CD3ζ) is the central component of the TCR-CD3 complex and is crucial for recognizing T cells and responding to antigens. Every subunit of CD3 has ...

CYAD-01, one of Celyad's lead candidates, is an autologous NKG2D-based chimeric antigen receptor T-cell (CAR-T) therapy construct, consisting of a full-length native human NKG2D gene fused with the ...

To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T persistence and function. Additionally, there is a growing trend towards ...

Please provide your email address to receive an email when new articles are posted on . The world of cancer cell therapy continues to evolve, and the next breakthrough may include T cells genetically ...

Cartoon describing the synthesis process of the Nanogel (backpack). This material relates to a paper that appeared in the Nov. 11, 2020, issue of Science Translational Medicine, published by AAAS. The ...

Henry M. Jackson Foundation for the Advancement of Military Medicine The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. has selected three promising Uniformed Services ...