Microglia play an important role in neuronal protection and damage. However, the molecular and cellular relationship between microglia and neurons is unclear. We carried out a prospective study to ...

Toll-like receptor 4 (TLR4) antibody, protein kinase B (AKT) inhibitor, LY 294002, and glycogen synthase kinase 3β (GSK-3β) inhibitor, LiCl, were used by Yu He and colleagues from Nantong University, ...

BURLINGAME, Calif.--(BUSINESS WIRE)--Tallac Therapeutics, Inc., a privately held biopharmaceutical company harnessing the power of innate and adaptive immunity to fight cancer, today announced the U.S ...

Preliminary safety, pharmacokinetics (PK), pharmacodynamics (PD) and clinical efficacy of uliledlimab (TJ004309), a differentiated CD73 antibody, in combination with atezolizumab in patients with ...

Background. We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic ...

Interleukin-1 receptor-associated kinase 4 (IRAK-4) plays a critical role in the modulation of inflammatory responses through Toll-like receptor (TLR) and IL-1R signaling. Gilead Sciences Inc. is ...

Interferons (IFNs) are a group of cytokines that were first identified in 1957, where they were found to interfere with a viral infection. IFNs possess several important properties, including ...

The worldwide spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the global coronavirus disease 2019 (COVID-19) pandemic. To date, this pandemic has infected over 207 ...

Toll-like receptor (TLR) and saponin adjuvants have each improved vaccine potency and safety. Now, researchers at Stanford University report that combining them in a nanoparticle format improves not ...

Interleukin-1 receptor-associated kinase 4 protein levels were elevated in hidradenitis suppurativa (HS)lesions. KT-474, demonstrated preliminary clinical activity in HS and atopic dermatitis patients ...