DALLAS (July 17, 2005) -- By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a ...

Researchers have found a genetic variant that doubles the likelihood that people will have calcium deposits on their aortic valve. Such calcification, if it becomes severe, can cause narrowing or a ...

Developed by Shiyou Chen and Dunpeng Cai, faculty in the School of Medicine’s Department of Surgery, the "humanized" model is currently being used to test the efficiency of various drugs and medicines ...

The first ever "humanized" model for aortic valve calcification paves the way for testing potential treatments.

Many physicians have come to believe that aortic valve sclerosis and subsequent aortic valve stenosis are due to the atherosclerotic process. Pohle and colleagues [1] recently made some observations ...

A genetic component is believed to play an important role in valvular heart disease, but the specific genes involved have not been identified. Now an interntional group of researchers has identified ...

Calcific aortic stenosis in the elderly is the number one cause of surgical valve replacement in the US and Europe. The incidence of calcific aortic stenosis is increasing as the general age of the ...

Although significant progress has been made in the understanding of the pathogenesis of CAVD, there are still many uncertainties. Current knowledge of the precise interplay of genetics, clinical risk ...

The Phase 2, randomized, double-blind clinical trial included 23 patients randomized to either 200 mg ataciguat (n=12) or placebo (n=11) once daily for a 12-month period. The primary Phase 2 clinical ...

Please provide your email address to receive an email when new articles are posted on . Mitral annulus calcification may be an independent risk factor for all-cause mortality and was more common among ...

DALLAS – July 17, 2005 – By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a common ...