This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The ...
The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...
Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in ...
This is a preview. Log in through your library . Abstract CD82 and CD9 are tetraspanin membrane proteins that can function as suppressors of tumor metastasis. Expression of CD9 and CD82 in transfected ...
The Wnt/β-catenin signalling pathway is a fundamental regulator of embryonic development, tissue homeostasis, and regeneration 1. Central to this pathway is the β-catenin destruction complex (DC), a ...
The Wnt/β-catenin signalling pathway is a fundamental regulator of embryonic development, tissue homeostasis, and regeneration 1. Central to this pathway is the β-catenin destruction complex (DC), a ...
Phase I experience with first in class TnMUC1 targeted chimeric antigen receptor T-cells in patients with advanced TnMUC1 positive solid tumors. Generation of a HuTCR mouse platform-derived ...
A research team at the School of Biological Sciences, the University of Hong Kong (HKU), has revealed novel cellular and molecular interactions between cancer cells and tumour-associated macrophages ...
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