This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The ...
To investigate whether activating the Wnt/β-catenin signalling pathway differentially promotes fracture healing in aged and adult individuals. CatnbTM2Kem, Catnblox(ex3) and wild-type adult and aged ...
Wnt signaling plays a critical role in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling cascade of Wnt signaling, little is known ...
The same message can be interpreted differently by different individuals – also among cells. This is shown in a study by researchers at Linköping University who studied cell communication through Wnt ...
The Wnt/β-catenin signalling pathway is a fundamental regulator of embryonic development, tissue homeostasis, and regeneration 1. Central to this pathway is the β-catenin destruction complex (DC), a ...
The Wnt/β-catenin signalling pathway is a fundamental regulator of embryonic development, tissue homeostasis, and regeneration 1. Central to this pathway is the β-catenin destruction complex (DC), a ...
Comprehensive characterization of KRAS mutations and inter-relation with primary tumor location in colorectal cancers. This is an ASCO Meeting Abstract from the 2023 ASCO Gastrointestinal Cancers ...
ANN ARBOR, Mich. – Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful.
The human gut renews itself faster than any other tissue: every few days, new cells are created from specialized stem cells.
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