Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology ...

This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The ...

An investigator-developed drug has shown preclinical efficacy and is worth testing in clinical trials in aggressive breast ...

The human gut renews itself faster than any other tissue: every few days, new cells are created from specialized stem cells.

A specific form of epigenetic aging, ACCA drift, accumulates in intestinal stem cells, silencing key genes through hypermethylation. Driven by age-related inflammation, weakened Wnt signaling and ...

Using microfluidic models to evaluate whether monocyte preconditioning plays a role in tumor-associated macrophage mediated resistance to hormone therapy in men with prostate cancer.