What will be the winners and the losers this week at the U.S. box office? Four new movies enter theaters this weekend led by Novocaine, Paramount's comedy-thriller from directors Dan Berk and Robert Olsen.

After starring in last month’s AI thriller “Companion,” Jack Quaid is back at the box office this weekend with “Novocaine,” an action comedy where he plays a man who can’t feel pain. The R-rated film from Paramount has made $1.

The hero at the heart of “Novocaine” can't feel pain. The new film in theaters Friday stars Jack Quaid as Nate, an ordinary guy whose disability becomes his saving grace when attempting to save a hostage from violent criminals.