AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses, even those that do not disrupt the ...

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis that modulates numerous metabolic pathways. Despite substantial interest in therapeutically targeting AMPK — ...

Isomeranzin (ISM) binds to Gnas, activating adenylyl cyclase and elevating intracellular cAMP levels. This activation ...

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the ...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

A new study describes how hyperactivation of AMP-activated protein kinase promotes neurodegeneration in Huntington's disease. A new study describes how hyperactivation of AMP-activated protein kinase ...

Researchers have developed a new system that lets them study in more detail than ever exactly how, where and when the metabolic protein AMPK carries out its molecular and therapeutic functions. The ...

Postoperative cognitive dysfunction is associated with neuronal apoptosis, which may result from post-surgery inflammation, the phosphorylation of tau protein and the accumulation of amyloid in aged ...

Most breast cancers utilize the female hormone estrogen to grow, so drug-induced estrogen deprivation is used as a treatment in many patients. However, cancer will recur in one-third of these patients ...

A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of ...