Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

Isomeranzin (ISM) binds to Gnas, activating adenylyl cyclase and elevating intracellular cAMP levels. This activation ...

Our findings demonstrate that SOX9 overexpression alleviates hepatic lipid accumulation in MASH by activating the AMPK pathway. These results highlight SOX9 as a promising therapeutic target for ...

Evaluation of EZH2 SNPs in cholangiocarcinoma patients. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not include a full text component.

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...

Activating the PPARβ/δ-AMPK metabolic pathway could be an effective strategy to tackle the most common chronic liver disease in the world’s population. A study led by Manuel Vázquez Carrera, group ...

Yong Yi, Deshi Chen, Juan Ao, Wenhua Zhang, Jianqiao Yi, Xiaokun Ren, Junjie Fei, Fengtian Li, Mengmeng Niu, Hu Chen, Yangkun Luo, Zhijun Luo, Zhi-Xiong Jim Xiao Proceedings of the National Academy of ...

We know caffeine is good for an alertness boost first thing in the morning or during an afternoon lull, but researchers have also linked the compound to healthy aging – and a new study takes a close ...

Coffee doesn’t just perk up your brain, it might be flipping important switches inside your cells, too. While known for boosting alertness and offering some health perks, caffeine also tinkers with ...

Your morning coffee may offer more than just a quick jolt of alertness. New research from Queen Mary University of London reveals caffeine's remarkable ability to extend the lifespan of cells by ...