UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors ...

Heterotrimeric G proteins, comprising Gα, Gβ and Gγ subunits, are central to the transduction of extracellular signals into precise intracellular responses in plants. These proteins not only regulate ...

For more than 70 years, hydralazine has helped doctors lower dangerously high blood pressure during medical emergencies, ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Scientists at the University of North Carolina School of Medicine have made a breakthrough in understanding how cells respond ...

The design of new calcium channels, built bottom-up from scratch, was reported last week in Nature. "Biochemists have been studying ion channels for decades and debating about how they work for almost ...

Research into Kisspeptin-10 has expanded well beyond its initial discovery as a metastasis suppressor fragment.

In their new study, the LJI scientists are the first to show that GPR25 is induced by a signaling molecule called TGF-β.

Chemerin is a key adipokine that regulates lipid metabolism and insulin sensitivity, and thus is involved in many metabolic ...